ALTERED PURKINJE CELL MIRNA EXPRESSION AND SCA1 PATHOGENESIS

Altered Purkinje cell miRNA expression and SCA1 pathogenesis

Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder caused by polyglutamine repeat expansions in Ataxin-1.Recent evidence supports a role for microRNAs (miRNAs) deregulation in SCA1 pathogenesis.However, the extent click here to which miRNAs may modulate the onset, progression or severity of SCA1 remains largel

read more


The Status of Conditional Syllogism in Syllogistics

The form of the conditional syllogism resembles that of the categorical syllogism, while its subject matter is at least a conditional premise, but its conclusion is always conditional conjunctive or disjunctive.This mixed structure to which we apply majicontrast red the rules of the categorical syllogism, is a structure of which Aristotle did not h

read more

Historical dynamics and current environmental effects explain the spatial distribution of species richness patterns of New World monkeys

Background Why biodiversity is not uniformly distributed on the Earth is a major research question of biogeography.One of the most striking patterns of disparity in species distribution are the biodiversity hotspots, which generally do not fit with the distribution of relevant components of the Neotropical biota.In this study, we assess the proxima

read more