Altered Purkinje cell miRNA expression and SCA1 pathogenesis
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder caused by polyglutamine repeat expansions in Ataxin-1.Recent evidence supports a role for microRNAs (miRNAs) deregulation in SCA1 pathogenesis.However, the extent click here to which miRNAs may modulate the onset, progression or severity of SCA1 remains largel